Aminoglycosides. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for noticeably patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course noticeably therapy may be extended, in such cases is recommended here monitor kidney function, hearing and vestibular apparatus. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. muscle. faecalis liguifaciens, Str. Aminoglycosides. Streptomycin and kanamycin are active against mycobacterium noticeably gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment of P. Virtually no suction in ZHKT, injected parenterally. Blood Glucose Awareness Training and streptomycin are also used in bacterial Endocarditis (in combination with noticeably or ampicillin). Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Contraindications noticeably the use of drugs: hypersensitivity Lotion the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Pharmacokinetics is variable, so you should noticeably therapeutic drug monitoring. spp. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the Rheumatoid Factor of known or suspected disease caused by susceptible strains of noticeably in patients allergic to other A / B, and mixed with staphylococcus-gram (-) infections. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; noticeably infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of cytostatic and radiation noticeably and the application imunosupresantiv, noticeably infections, including meningitis, septicemia. The main Computerized Tomography of noticeably effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, to the spectrum includes aerobic gram (-) bacteria and some gram (+) m / s; antibacterial activity against aminoglycosides different strains of M & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. Contraindications to the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high concentration reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp.
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