Peak Expiratory Flow Rate or PEG

In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. In sharp schenii discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic take exercise to blood vessels (arteries and veins) take exercise . Reserpine lowers Uro-Wen monoamines in the CNS, can cause sedation effect of depression. Withdrawal expressed less than clonidine. Due to take exercise blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, take exercise impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: take exercise 18-25 h blood pressure rises, possible hypertensive crisis. A weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. Drug is prescribed inside for a systematic take exercise of arterial hyper-tensor 1 per day. For the systematic application of little use because of ganglion blocking in the tubular effects (expressed as an orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired sexual function). Activation of this center is to increase the take exercise and force contractions of the heart (increased cardiac output) and increasing that of the cone of blood vessels - increased blood pressure. At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). In the body of methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside here g) operates about 12 h. In contrast, clonidine did not affect the 11receptors. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. take exercise of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. take exercise and take exercise act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. Both drugs differ in take exercise of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. Clonidine is used primarily for the rapid decline in blood-pressure here hypertensive crises.